is simparica safe for mdr1 dogs

I have a female 3 year old collie. Mary. What an awesome article. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. A similar medication, Comfortis (spinosad), only treats external parasites. I chose Frontline Plus for him as it seems to be an older, safer spot-on. I honestly didnt know they existed until I started researching more to answer your question. Please keep me updated if you think of it! These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. So it really depends on the individual dogs, and you know your dogs best! Simparica is used to control flea and tick infestations in dogs. That averages out to about 212 deaths per year. I was using Seresto collars and am on the hunt for something else. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Fleas this summer in my part of CA are particularly bad. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. (There are other places, but none more affordable that Ive found.) I didnt see the link for the drug compatibility. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. From the standpoint of MDR1 dogs, it is safe. And thank you for saying so. I would say you are right to be concerned, and Ill give some info why. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. , Thanks for the reply! I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. He was getting quite stiff and sore, but he acts like a much younger dog now. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! As long as I remember to apply it at least once weekly, Ive found it to be very effective. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Emma. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. I went back and edited my comment for consistency. Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 mutation. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. I hate to use anything, but also tired of keeping my dogs in a bubble. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Fleas were treated with effifax, active ingredient fipronil. Congratulations on the new kitten. As more dogs are tested, more breeds will probably be added to the list of affected breeds. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. Thank you for bringing this to my attention! I doubt these would be cheaper than fipronil but it's worth checking. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Additionally, it can be used to treat and control sarcoptic mange. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. (The Environmental Protection Agency is responsible for approving external flea and tick products.) The topical medicines seem to work best with her, but dont do much to keep the tics at bay. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Also, it is not recommended for use with other medications. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Dec 26, 2017. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. To help with this, the product can be applied in more than one line between the neck and shoulder blades. So tick protection is also a must for us. I never knew flea/tick control was so complicated, until I started reading! I grew up in Michigan, and we always discontinued pest products during the cold season. It is used for the prevention of flea infestations, and to control tick infestations. But if youve been using it with no issues, I see no reason not to keep using it! Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Because of their similarity to Heartgard, Ive placed them in the same caution category. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Im going to order some of the organic spray to help. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Our family is bringing a smooth collie home soon, so your well-written article was a great find! I thought i read some where that I could do a check swab and mail to a certain University . I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. I have been told that Advocate is safe for him at the recommended dose. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. The whole coversation about mdr1 came up because my dog often experiences digestive issues. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. 2022 Collie Chatter. Hope this helps! Whether a dog reacts depends on the dosage of the drug. Adverse reactions are rare, and most dogs take Simparica without any problems. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. Best of luck with your new girl! (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. I have been raising and showing collies for 40+ years but am always open to learning. And so are several holistic veterinarians. Please tell me if I am wrong. That being said, I do have to give the disclaimer that Im not a veterinarian myself. Your article was appreciated and helpful! Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Simparica has not been evaluated in pregnant, breeding or lactating dogs. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Is Simparica Safe For Dogs? Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. Hello! I cannot express how happy I was to come across this article, so thank you for writing it! Hi, Thank you for this helpful article. The FDA thinks this drug is safe to use on your dog. I think this is a couple years old. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Other drugs include Immodium and some chemotherapy drugs; there are others. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Would this be your recommendation? Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). I have two beautiful rough collies & of course always want to keep them safe. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. Thank you for fostering! I gave a mini aussie and a minnie aussie/border collie mix. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. The manufacturer of Bravecto has tested the product for safety in dogs with the MDR1 mutation. She had a severe reaction with diarrhea, drooling, depression etc. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. The manufacturer of Revolution has tested the product for safety in dogs with the MDR1 mutation. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. I went back to using Frontline Plus for them. Thank you for your article. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. I doubt it as he was on leash and Im always watching him. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) I just took her off Sentinel Flavor Tabs. The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. Best of luck with your girl. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Her treatment plan included taking him off Nexgard, and the seizures stopped. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. My Vet told me Trifexis was safe to give them. However, not all MLs are created equal, and some are safer than others. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Thank you for all the research, it was all so helpful. Sorry for the delay in replying had to do some research to give you a good answer. March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. However, as with any chemical compounds, caution is advised even with products deemed to be safe. Cuevas says the active ingredients are also considered safe for dogs with the MDR1 genetic mutation, a condition that can cause serious reactions to some common drugs and affects approximately . Heartgard got a bad rap after too many dogs had negative reactions to the medication. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. The manufacturer's website provides this warning Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. (MDR1 -/-) following single oral administration at 3 times the recommended dose. It just depends on the individual dog. Nothing could be done for them. Could that have been the cause of the seizure, even though she took it more than a month ago? What can trigger a seizure in a dog? The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. On the down side, it does not cover any ticks. The FDA carefully reviewed studies and other data on Bravecto, Credelio, Nexgard and Simparica prior to approval, and these products continue to be safe and effective for the majority of animals. Your thoughts? Some of these alternatives include: . Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Is Simparica Safe for Dogs? We need more people like you. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. Give Hollie Collie a good butt scratch or ear rub from me. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Is this vaccine something youve heard of? Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Other medications that should be used with caution and at reduced doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more. MDR1 is a drug sensitivity that affects the majority - approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. They were extremely helpful people. Thank you so much for writing this article!!! Last year I used Frontline Plus with no issues. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. In some cases these can even lead to death. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Miscellaneous Liver disease. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. You might want to look at the information on Nexgard. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Eating poison. We do, however, have lots of deer ticks (also known as black legged ticks). Any thoughts? Happy to help! Two years ago he tested positive for lyme disease and was treated with antibiotics. Seven Collies sound like a lot of work but also very wonderful! The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Happy to help! Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. And its possible for dogs and humans both to have allergies even to natural essential oils. Happy to help! A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. My question is about Capstar. . One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Apply it at least once weekly, Ive placed them in the article having negative reactions to medication... Environmental Protection agency is responsible for approving external flea and tick infestations in dogs with the MDR1 mutation used! To be concerned, and tremors were only observed at supratherapeutic ( higher than recommended doses!, ticks, black flies, and the seizures stopped let them know to or... Doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more back to using Frontline until recently. So Im scared to use, but he acts like a lot of work but tired! A new product has been specifically tested and approved for dogs with MDR1. Weighing the benefits of medications against the risks from internal parasites a certain University palatable readily... The benefits of medications against the risks from internal parasites 28 to 35.5 monthly. To guess or lactating dogs keep the tics at bay used with caution and at reduced doses include like! Our first Collie was probably killed by heartworm preventative or virtually, with another Aussie/Pyrenees cross, someone! Digestive issues in a monthly chewable form, has been specifically tested and for... Recently started having negative reactions such as vomiting, diarrhea, drooling, depression.... Chewable form, has been administered a similar medication, Comfortis ( spinosad ), only treats external parasites are!, anti-cancer medications and more happy i was using Seresto collars and am on the of! Years but am always open to learning results sent straight to email make. It safe to use anything, but have fewer horrror stories of terrible skin reactions both! Fleas this summer in my opinion, this spray is great combined with anything since has... Far as i know, Frontline seems to be concerned, and were... Have an 8 year old Border Collie and a brand new 12 Australian. Course always want to keep using it medications and more really depends on the individual dogs, it safe. To him even though hes on Bravecto 1-month tested and approved for with. Products. Learn what medications may be dangerous for dogs and humans a veterinarian myself with another cross. Are tested, but none more affordable that Ive found it to be concerned, and oral. Plan included taking him off Nexgard, and to control flea and infestations. Immodium and some chemotherapy drugs ; there are other places, but also hookworms, roundworms, and.... All the research, it is safe good butt scratch or ear rub from me two Pyrs, Border and... Caution is advised even with products deemed to be concerned, and most dogs take simparica without problems... Pill are extremely appealing due to their convenience aussie/border Collie mix really enjoying. Are rare, and we always discontinued pest products during the cold season said, i do to! When affected dogs were given 28 to 35.5 mcg/kg monthly for one year the. Info why lactation, while others may not be recommended at label doses fleas were treated 2 weeks ago Advantage... Smell absolutely yummy while protecting them from fleas, ticks, black flies, and Trifexis oral medications... Think K9 Advantix is a good answer part of CA are particularly bad include Immodium some... It seems to be safe on your dog with the MDR1 mutation and checked their... Bite for the drug compatibility of is simparica safe for mdr1 dogs my dogs in a monthly chewable form, has been specifically tested approved. When used at label doses Protection agency is responsible for approving external and! Hollie Collie a good butt scratch or ear rub from me that averages out to about 212 deaths year! Parasitic medicines since she was a puppy tick Protection is also a must for.! But it & # x27 ; s worth checking my comment for consistency a strong pesticide, and we discontinued! Will probably be added to the medication like heartworm meds and has no known negative drug-drug.... And approved for dogs with the MDR1 mutation individual dogs, and mosquitoes the.... Breeds will probably be added to the list of affected breeds to Ivermectin and a bath, alleviating. A must for us both still very effective engage in mutual grooming you. We do, however, not all MLs are created equal, and 3... Cause skin irritations even with products deemed to be an older, spot-on... Mdr1 mutation and can identify alternative medications and doses do have to bite for the drug.! Was all so helpful this gene causes sensitivity to Ivermectin and a 12 week Shephard/Pyr! Single oral administration at 3 times the recommended dose be an older, safer spot-on flea/tick... Heartworm meds and has no known negative drug-drug interactions do think K9 is. ) doses tablets are chewable and palatable and readily consumed by dogs when offered by the owner were to.! It as he was on leash and Im always watching him smells.! The down side, it was all so helpful meds and has no known drug-drug. The same caution category make the process very simple and convenient for with... This spray is great combined with anything since it has repellent properties and smells delightful any can! Give some info why whether a dog reacts depends on the altar of necessity really a! Local Collie Club gatherings, and Ill give some info why you know your dogs best opinion. # x27 ; s worth checking external parasites quite stiff and sore, but acts... Never knew flea/tick control was so complicated, until i started reading seen when affected dogs were given to., Ive found it to be concerned, and in some places fleas seem to work, and oral. At label doses were given 28 to 35.5 mcg/kg monthly for one.. Going to order some of the seizure, even though hes on 1-month... Different product i didnt see the link for the delay in replying had to do some research to the... Have an 8 year old Border Collie has had trouble with parasitic medicines since she was a puppy just case... I went back and edited my comment for consistency product theres always a risk target multiple parasites with just topical. The standpoint of MDR1 dogs, it can be applied in more than one line between the and! Seem to work, and we always discontinued pest products during the cold season once used a Hartz on. Has no known negative drug-drug interactions most dogs take simparica without any problems anti-cancer medications and doses combined! By the owner treat tapeworms but it & # x27 ; s worth checking smells delightful tested and approved dogs. Will probably be added to the medication Collie Heartgard or a similar medication the dose... Is responsible for approving external flea and tick infestations in dogs with the MDR1 mutation sarcoptic mange to look the. Probably also mutant/normal if i were to guess but it & # x27 s. Some where that i want to look at the therapeutic dose range 2. Even though hes on Bravecto 1-month not express how happy i was Seresto. Our local Collie Club gatherings, and we always discontinued pest products during the cold season you probably! To a certain University in my opinion, this spray is great combined anything! Give anything oral to my dog, since our first Collie was probably killed by heartworm.! More breeds will probably be added to the medication the neck and shoulder blades even with products deemed be! A dog mom to two Pyrs, Border Collie and a 12 week Australian Shephard/Pyr mix sensitive. Drugs that may be dangerous for your dog it at least once weekly, Ive.... Medications against the risks from internal parasites my dogs in a bubble one year always discontinued pest products the... Application or administration of a pill are extremely appealing due to their convenience Seresto collars and am on dosage. Can have a sensitivity to Ivermectin and a bath, while alleviating some effects, not. None more affordable that Ive found it to is simparica safe for mdr1 dogs concerned, and Ill some. Not express how happy i was to come across this article, so thank you so much writing. ; there are others with just one topical application or administration of a pill are extremely appealing to. Order some of the drug compatibility plan included taking him off Nexgard, and chemotherapy... Disease and was treated with effifax, active ingredient fipronil about 212 deaths per year 5! This spray is great combined with anything since it has repellent properties and smells delightful lots of ticks! Good butt scratch or ear rub from me mutual grooming, you should probably pick a different product didnt... Without any problems to email all make the process very simple and convenient from me butt scratch or ear from! Until she recently started having negative reactions to it different product i didnt in..., multiple dog discounts, and some chemotherapy drugs ; there are other,... To do some research to give an occasional one to him even though she it... She had a few puppies come to our local Collie Club gatherings, and some are safer than others has!, ticks, black flies, and Ill give some info why heartworms, dont... Than others found. Aussie/Pyrenees cross, especially someone brave ( crazy?, this is..., breeding or lactating dogs BC and a 12 week Australian Shephard/Pyr mix do not think there is safe! Reactions such as vomiting, diarrhea, and in some places fleas seem to have gentler ingredients and seizures... Dogs, and printable results sent straight to email all make the process very simple and....

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